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DEMADEX (TORSEMIDE): DOSAGE AND ADMINISTRATION

General

Demadex (Torsemide/Torasemide) tablets may be given at any time in relation to a meal, as convenient. Special dosage adjustment in the elderly is not necessary.

Congestive Heart Failure

The usual initial dose is 10 mg or 20 mg of once-daily oral Demadex. If the diuretic response is inadequate, the dose should be titrated upward by approximately doubling until the desired diuretic response is obtained. Single doses higher than 200 mg have not been adequately studied.

Chronic Renal Failure

The usual initial dose of Torsemide/Torasemide (Demadex) is 20 mg of once-daily oral Demadex. If the diuretic response is inadequate, the dose should be titrated upward by approximately doubling until the desired diure tic response is obtained. Single doses higher than 200 mg have not been adequately studied.

Hepatic Cirrhosis

The usual initial dose is 5 mg or 10 mg of once-daily oral Torsemide/Torasemide (Demadex) tablets, administered together with an aldosterone antagonist or a potassium-sparing diuretic. If the diuretic response is inadequate, the dose should be titrated upward by approximately doubling until the desired diuretic response is obtained. Single doses higher than 40 mg have not been adequately studied.

Chronic use of any diuretic in hepatic disease has not been studied in adequate and well­controlled trials.

Hypertension

The usual initial dose is 5 mg once daily. If the 5 mg dose does not provide adequate reduction in blood pressure within 4 to 6 weeks, the dose may be increased to 10 mg once daily. If the response to 10 mg is insufficient, an additional antihypertensive agent should be added to the treatment regimen.

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