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DEMADEX (TORSEMIDE): PRESCRIBING INFORMATION
Demadex (Torsemide) is a diuretic of the pyridine-sulfonylurea class. Its chemical name is 1-isopropyl-3-[(4-m-toluidino-3-pyridyl) sulfonyl] urea.
Its empirical formula is C16H20N4O3S, its pKa is 7.1, and its molecular weight is 348.43.
Torsemide is a white to off-white crystalline powder. The tablets for oral administration also contain lactose NF, crospovidone NF, povidone USP, microcrystalline cellulose NF, and magnesium stearate NF.
INDICATIONS AND USAGE
Demadex (Torsemide) is indicated for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Use of torsemide has been found to be effective for the treatment of edema associated with chronic renal failure. Chronic use of any diuretic in hepatic disease has not been studied in adequate and well-controlled trials.
Demadex (Torsemide) tablets are indicated for the treatment of hypertension alone or in combination with other antihypertensive agents.
DOSAGE AND ADMINISTRATION
Demadex dosage and administration
Demadex clinical pharmacology
Demadex clinical effects
Torsemide (Demadex) is contraindicated in patients with known hypersensitivity to Demadex or to sulfonylureas.
This medication is contraindicated in patients who are anuric.
Demadex drug interactions
USE IN SPECIAL POPULATIONS
Demadex use in special populations
Demadex adverse reactions
There is no human experience with overdoses of Demadex (Torsemide/Torasemide), but the signs and symptoms of overdosage can be anticipated to be those of excessive pharmacologic effect: hypovolemia, dehydration, hypotension, hypokalemia, hyponatremia, hypochloremic alkalosis, and hemoconcentration. Treatment of overdosage should consist of fluid and electrolyte replacement.
Laboratory determinations of serum levels of torsemide and its metabolites are not widely available.
No data are available to suggest physiological maneuvers (e.g., maneuvers to change the pH of the urine) that might accelerate elimination of torsemide and its metabolites. Torsemide is not dialyzable, so hemodialysis will not accelerate elimination.
Demadex (Torsemide) for oral administration is available as white, scored tablets containing 5 mg, 10 mg, 20 mg, or 100 mg of torsemide. The tablets are supplied in bottles of 100 as follows:
Demadex 5 mg: elliptical
Demadex 10 mg: elliptical
Demadex 20 mg: elliptical
Demadex 100 mg: capsule shaped
Each tablet is debossed on the scored side with the logo BM and 102, 103, 104, or 105 (for 5 mg, 10 mg, 20 mg, or 100 mg, respectively). On the opposite side, the tablet is debossed with 5, 10, 20, or 100 to indicate the dose.
Store at 15° to 30°C (59° to 86°F).
Manufactured and distributed by Roche, Meda pharmaceutical companies and their divisions.
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